Northwest Arkansas Clinical Trials Center has been a dedicated dermatology research center for more than 7 years. The research center is located in the heart of Northwest Arkansas, home to a regional population of more than 500,000 residents and two large college campuses. The clinical trials center has over 1500 square feet solely dedicated to dermatology research and research subjects. The center includes a reception area, examination rooms, laboratory, locked and temperature monitored investigational product ambient storage, study coordinator offices, and temperature monitored refrigerator and -20 C freezer. All equipment undergoes certification annually.

The combined clinical trial team experience in phase I-phase IV studies exceeds 50 years. Investigational product formulation experience includes oral, intravenous, topical and other parenteral routes. All personnel have certified GCP training and most are IATA certified. The staff is very familiar with the variety of electronic data capture (EDC) platforms and are very proficient in data entry.

The center and personnel have clinical trial experience in the following dermatologic conditions in pediatric, adolescent and adult populations:

  • Atopic Dermatitis
  • Alopecia
  • Hyperhidrosis
  • Psoriasis
  • Acne
  • Common Warts
  • Seborrheic Keratosis
  • Rosacea
  • Hidradenitis suppurativa
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Acanthosis nigricans: This skin condition causes areas of skin to darken and thicken as shown here on this 15-year-old girl's hands.

Acanthosis nigricans: Overview

What is acanthosis nigricans?

Acanthosis nigricans (ay-can-THOE-sis NIE-gri-cans) (AN) 
is a skin condition that causes one or more areas of skin to darken and thicken. The affected skin often feels velvety.

People who get this skin condition sometimes mistakenly believe that a dye or something else they touched has discolored their skin. Vigorous scrubbing will not get rid of the darkened skin.

Acanthosis nigricans is not contagious. It is not harmful. Sometimes, it is a warning sign of a health problem that requires medical attention. For this reason, it is important to see a dermatologist if you notice an area of darker, thicker skin.

When to see a dermatologist

If you notice a change to your skin, you should see a dermatologist. Small changes may seem like nothing. Sometimes a small change is an early warning sign. AN can be a sign of pre-diabetes, which increases your risk of getting diabetes. Making lifestyle changes before diabetes develops can prevent diabetes.

Some people get AN from a medicine that they are taking. Changing medicines might be an option for you. Other times, these dark patches have no connection to any medical condition. A dermatologist can help you find out what’s causing your skin changes.

Image used with permission of the American Academy of Dermatology National Library of Dermatologic Teaching Slides.

 

References:
Habif TP, Campbell JL, Chapman MS, et al. “Acanthosis nigricans.” Dermatology DDxDeck. Mosby. 2006.
Hermanns-Le T, Scheen A, Pierard GE. “Acanthosis Nigricans Associated with Insulin Resistance.” Am J Clin Derm. 2004;5(3):199-203.
Kapoor S. “Diagnosis and treatment of acanthosis nigricans.” Skinmed. 2010 May-Jun;8(3):161-4; quiz 165.
Sinha S, Schwartz RA. “Juvenile acanthosis nigricans.” J Am Acad Dermatol. 2007;57:502-8.
Yosipovitch G, DeVore A, Dawn A. “Obesity and the skin: Skin physiology and skin manifestations of obesity.” J Am Acad Dermatol. 2007;56:901-16.


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Northwest AR Clinical Trials Center, PLLC

(479) 876-8049
500 S 52nd St Rogers, AR 72758-8600